Use of the GRADE approach in systematic reviews of animal studies




Poster session 2


Monday 24 October 2016 - 15:30 to 16:00


All authors in correct order:

Deng W1, Wei D2, Yao L2, Wang X2, Wang Q2, Chen Y2
1 Second Hospital of Lanzhou University, China
2 Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province; Evidence-Based Medicine Center of Lanzhou University; Chinese GRADE Center, China
Abstract text
Background: The application of GRADE (Grading of Recommendations Assessment, Development and Evaluation) in systematic reviews (SRs) of animal studies can promote the translation from bench to bedside.

Objectives: We aim to explore the use of GRADE in SRs of animal studies.

Methods: We used a theoretical analysis method to explore the use of GRADE in SRs of animal studies and applied in one SRs of animal studies. Meanwhile, we discussed our results with relevant experts in two international conferences.

Results: Five downgrading factors were considered in SRs of animal studies.
1. Risk of bias: the SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation) tool can be used for assessing the risk of bias of animal studies.
2. Indirectness: we can assess indirectness in systematic reviews of animal studies from the PICO (population, intervention, comparator, outcomes).
3. Inconsistency: similarity of point estimates, extent of overlap of confidence intervals and statistical heterogeneity are also suitable to evaluate inconsistency of evidence from animal studies.
4. Imprecision: optimal information size (OIS) and 95% confidence intervals (CIs) are also suitable for systematic reviews of animal studies, like those of clinical trials.
5. Publication bias: we need to consider publication bias comprehensively through qualitative and quantitative methods.

Conclusions: The methods for the use of GRADE in systematic review of animal studies are explicit. However, the principle about GRADE in developing the policy based on the evidence from animal studies when there is an emergency of public health.